The framework includes some nice controls, including one to scroll to a point on the page when the server response returns. My main concern is that by using this framework, navigating between pages doesn't change the URL in the address bar. It also seems to break my back button in Firefox 1.5.
That's a shame because this is a great idea - abstracting AJAX to the point where you don't have to worry about it at all. But I think there are limitations here that would stop me from using ComfortASP in anger.
In other news, here's a post on doing multiple concurrent XMLHTTPRequests from a single page.